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Ye-Guang CHEN

Ye-Guang CHEN

Tel：86-10-62784794

E-mail：ygchen(at)mail(dot)tsinghua(dot)edu(dot)cn

Research Area:

The molecular mechanism of cell signaling. His research interests concern how TGFbeta and Wnt signaling are regulated and aim to understand their roles in stem cell self-renewal and differentiation, embryogenesis, tissue fibrosis and tumorigenesis.

Selected Publications：

1. Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed J, Liao FF, Chen YG#, Xu H# 2012 Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration. Journal of Neuroscience, 32(44):155565-155576. .

2. Li, Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG#. 2012 BMP4 Signaling Acts via Dual Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells. Cell Stem Cell, 10:171-182.

3. Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG# 2012 PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22(10):1467-1478.

4. Shi Y, Ding Y, Lei YP, Yang XY, Xie GM, Wen J, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG#, Wang HY# 2012 Identification of novel rare mutations of DACT1 in human neural tube defects. Human Mutation, 33(10):1450-1455.

5. Li Z and Chen YG# 2012 Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells. Protein Cell, 3(6):401-404. (Perspective).

6. Yan X#, Zhang JY, Sun QY, Polygena T., Wu XP, Jolinda A.and Chen YG#. 2012 p21-activated Kinase 2 (PAK2) Inhibits TGF-_ Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad InteractionJournal of Biological Chemistry, 287(17):13705-13712.

7. Huang F, Chen YG# 2012 Regulation of TGF-beta Receptor Activity. Cell & Bioscience 2012, 2:9 (doi:10.1186/2045-3701-2-9) (Review) .

8. Chen YG# , Li, Z, Wang XF#. 2012 Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate. Cell Stem Cell, 10(3):231-232. (Preview).

9. Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X,Chen YG#, Jiang D#, Ning W# 2011 Fstl1 Is a BMP4 Signaling Antagonist in Controlling Mouse Lung Development.Proc Natl Acad Sci. USA, 108:7058-63.

10. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG# 2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.

11. Fei F, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD#,Chen YG# 2010 Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.

12. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X#, Chen YG# 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.

13. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG# 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

14. Ma J, Wang Q, Fei T, Han JD, Chen YG# 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

15. Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A,Chen YG# 2007 Smad7 antagonizes TGF-β signaling in the nucleus by interfering with functional Smad-DNA complex formation. Molecular and Cellular Biology, 27:4488-4499.

16. Zhang L, Zhou H, Su Y, SunS, Zhang H, Zhang L, Zhang Y, Ning Y, Chen YG#, Meng A# 2004 ZebrafishDpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117.