吝易

办公电话：+86 10 62798206

电子邮件：linyi@mail.tsinghua.edu.cn

 

研究方向

细胞中一些特定的生物大分子通过相分离形成无膜细胞器，从而对细胞内空间进行分隔，精确协调各种生化反应。病理状态下，蛋白质异常相变造成不溶性聚集，进而导致神经元死亡。我们希望系统性地研究生物大分子相变的分子机制及其对神经系统功能的影响，最终达到通过人工干预调控病理状态下的相变，从而治疗神经退行性疾病的目的。

 

代表性科研论文

 

• Yi Lin, Xiaoming Zhou, Masato Kato, Daifei Liu, Sina Ghaemmaghami, Benjamin P. Tu, and Steven L. McKnight, Redox-mediated Regulation of an Evolutionarily Conserved Cross-beta Structure Formed by the TDP43 LC Domain. (2020) PNAS. Nov 17;117(46):28727-28734

• Yi Lin^#, Eiichiro Mori^#, Masato Kato^#, Siheng Xiang^#, Leeju Wu, Ilmin Kwon and Steven L. McKnight, Toxic PR Poly- Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers. (2016) Cell. Oct 20; 167(3):789-802; #co-first authors

•  Dylan T. Murray^#, Masato Kato^#, Yi Lin, Kent R. Thurber, Ivan Hung, Steven L. McKnight, and Robert Tycko, Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains. (2017) Cell. Oct 19; 171(3):615–627; #co-first authors

•  Masato Kato, Yi Lin, Steven L. McKnight, Cross-β Polymerization and Hydrogel Formation by Low-Complexity Sequence Proteins. (2017) Methods. Aug 15; 126:3–11

• Siheng Xiang, Masato Kato, Leeju C. Wu, Yi Lin, Ming Ding, Yajie Zhang, Yonghao Yu, Steven L. McKnight, The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei. (2015) Cell. Nov 5;163(4):829-39