胡小玉

 

电子邮件：xiaoyuhu@tsinghua.edu.cn

电话：＋86-10-62795612（实验室）

 

研究方向：

1.巨噬细胞生物学包括巨噬细胞活化调控以及组织特异性巨噬细胞的功能

2.肠道上皮细胞在稳态维持和宿主防御中的作用

3.人类炎症与自身免疫性疾病分子机制

 

代表性科研论文：

1. Ji L, Zhao X, Zhang B, Kang L, Song W, Zhao B, Xie W, Chen L, Hu X. Slc6A8-mediated creatine uptake and accumulation reprogram macrophage polarization via regulating cytokine responses. Immunity 2019; 51:272-284

2. Liang S, Guo XK, Ou J, Huang R, Xue Q, Zhang B, Chung Y, Wu W, Dong C, Yang X, Hu X. Nutrient sensing by the intestinal epithelium orchestrates mucosal antimicrobial defense via translational control of Hes1. Cell Host & Microbe 2019; 25:706-718

3. Ning F, Li Y, Yu L, Zhang B, Liu Y, Zhao B, Shang Y, Hu X. Transcription factor Hes1 attenuates type I interferon-mediated immune responses via VEGF-C and WDFY1. Journal of Experimental Medicine 2019; 216:1396-1410

 

4. Shang Y, Coppo M, He T, Ning F, Yu L, Kang L, Zhang B, Ju C, Qiao Y, Zhao B, Gessler M, Rogatsky I, Hu X. The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation. Nature Immunology 2016; 17:930-937

5. Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz HH, Kitajewski J, Shi C, Weber S, Saftig P, Li YM, Ozato K, Blobel CP, Ivashkiv LB, Hu X. Notch-RBP-J signaling regulates IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012; 13:642-650