个人简介：
彭敏，目前受聘于清华大学基础医学院、清华-北大生命科学中心和清华大学免疫学研究所，任副教授、研究员、博士生导师。彭敏2005年本科毕业于四川大学华西医学中心临床医学专业，于2010年在北京协和医学院获得免疫学博士学位，2010-2017年在纽约纪念斯隆凯特琳癌症中心从事博士后研究, 研究方向为mTORC1调控机制和免疫代谢，相关研究成果以第一作者身份发表在Cell（2014）、Science（2016）及Nature（2017）等杂志，并获得纪念斯隆凯特琳癌症中心2015年度Postdoctoral Research Award（杰出博士后）荣誉称号。2017年，彭敏博士入职清华大学开展独立科研和教学工作，致力于使用高通量功能基因组学技术系统性地探索免疫学基本问题，尤其是记忆免疫记忆的本质和及其调控机制。自实验室建立以来，彭敏以通讯作者身份在Nature Immunology（2024），Journal of Experimental Medicine (2023, 2024), Journal of Clinical Investigations (2021) 及Cell Reports (2019) 等杂志发表研究成果，并获得中组部青年千人称号（2018）以及“求是”杰出青年学者奖(2019)。
科研领域：
My laboratory is committed to advancing T cell research, with a dual focus on elucidating the foundational biology of T cells and exploring their therapeutic potential in combating diseases. Our primary objective is to unravel the intricate mechanisms governing T cell expansion, contraction, persistence, and memory formation. Leveraging state-of-the-art technologies, we have recently achieved a groundbreaking milestone by inducing a novel state in T cells, termed Immortal-like and Functional (TIF). These reprogrammed TIF cells exhibit remarkable attributes, combining the near-limitless stemness reminiscent of iPSCs with the functional capabilities of mature T cells. This unique phenotype empowers them with unparalleled efficacy against various ailments, including tumors, viral infections, and numerous chronic diseases.
Presently, we are deeply engaged in investigating the underlying mechanisms and exploring the clinical applications of TIF. We are actively seeking postdoctoral fellows with a keen interest in T cell biology and immunotherapy, please reach out to us at pengmin@tsinghua.edu.cn.
学术成果：
1. Gang Jin*, Yanyan Liu*, Lixia Wang, Zihao He, Xiaocui Zhao, Yuying Ma, Yuting Jia, Zhuoyang Li, Na Yin, Min Peng. A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Nat Immunol. 2024. Accepted.
2. Lixia Wang*, Gang Jin*,Qiuping Zhou*, Yanyan Liu, Xiaocui Zhao, Zhuoyang Li, Na Yin, Min Peng. Induction of immortal-like and functional CAR T cells by defined factors. J Exp Med. 2024. In press
3. Ying Liu*, Yuying Ma*, Jing Xu*, Guangyue Zhang*, Xiaocui Zhao*, Zihao He, Lixia Wang, Na Yin, Min Peng. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. J Exp Med. 2023 Jun 5;220(6):e20221068.
4. Min Peng, Ming O. Li. Metabolism along the life journey of T cells. Life Metabolism. 2023, 002(001)
5. Na Yin*, Gang Jin*, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng. SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation. J Clin Invest., 2022 Oct 17, 130(20):e146272.
6. Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.
7. Ke Xu*, Na Yin*, Min Peng, Efstathios G Stamatiades, Sagar Chhangawala, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Kristelle J Capistrano, Chun Chou, Christina S Leslie, Ming O Li. Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses. Immunity. 2021. 54(5):976-87.
8. Ke Xu, Na Yin, Min Peng, Efstathios G Stamatiades, Amy Shyu, Peng Li, Xian Zhang, Mytrang H Do, Zhaoquan Wang, Kristelle J Capistrano, Chun Chou, Andrew G Levine, Alexander Y Rudensky, Ming O Li. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. Science. 2021. Jan 22;371(6527):405-10.
9. Mytrang H. Do, Xinxin Wang, Xian Zhang, Chun Chou, Briana G. Nixon, Kristelle J. Capistrano, Min Peng, Alejo Efeyan, David M. Sabatini, Ming O. Li. Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance. J Exp Med. 2020 Jan 6;217(1):e20190848.
10. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.
11. Min Peng*, Na Yin*, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484.
12. Jiangbin Ye, Wilhelm Palm, Min Peng, Bryan King, Tullia Lindsten, Ming O. Li, Constantinos Koumenis, Craig B. Thompson. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 2015 Nov 15; 29 (22): 2331-6.
13. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33.
14. Weiming Ouyang, Will Liao, Chong T. Luo, Na Yin, Morgan Huse, Myoungjoo V. Kim, Min Peng, Pamela Chan, Qian Ma, Yifan Mo, Dies Meijer, Keji Zhao, Alexander Y. Rudensky, Gurinder Atwal, Michael Q. Zhang, Ming O. Li. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 2012 Nov 22; 491(7425): 554-9
15. Min Peng,Sha Guo,Na Yin, Jing Xue, Lian Shen, Qing Zhao, Wei Zhang. Ectodomain shedding of Fcalpha receptor is mediated by ADAM10 and ADAM17. Immunology, 2010, 130(1): 83-91
16. Min Peng; Na Yin; Wei Zhang. Endocytosis of FcaR is clathrin and dynamin dependent but its cytoplasmic domain is not required. Cell Res, 2009, 20(2): 223-237