郭增才

电子邮件：zengcai.guo@gmail.com

 

研究方向：

本实验室的长期目标是理解大脑的高级认知功能（比如感知、决策及工作记忆）是如何由神经回路来实现的。我们将综合利用先进的技术（光遗传学、多通道电生理、双光子成像及定量行为学等）来研究小鼠在感知决策行为中的神经回路。

我们侧重研究以下几个问题：

1. 感知决策过程中需要哪些大脑区域

2. 感知决策过程中每一步需要哪些大脑区域

3. 感知决策过程中各脑区的神经信号和哪些行为参数有关

 

代表性科研论文：

1. N Li, T Chen, ZV Guo, C Gerfen, K Svoboda. A motor cortex circuit for motor planning and movement. Nature, in press.

2. ZV Guo, SA Hires, N Li, DH, O’Connor, T Komiyama, E. Ophir, D Huber, C Bonardi, K Morandell, D Gutnisky, S Peron, N Xu, J Cox, K Svoboda. Procedures for behavioral experiments in head-fixed mice. Plos one. 2014, 9(2): e88678.

3. ZV Guo, N Li, D Huber, E Ophir, D Gutnisky, JT Ting, G Feng and K Svoboda. Flow of cortical activity underlying a tactile decision in mice. Neuron. 2014, 81, 179-94.

4. DH O’Connor, SA Hires, ZV Guo, N Li, J Yu, Q Sun, D Huber and K Svoboda. Neural coding during active somatosensation revealed using illusory touch. Nature Neuroscience. 2013, 16, 958-965.

5. Z Wei, ZV Guo, L Dudte, H Liang and L Mahadevan. Geometric mechanics of periodic pleated origami. Physical Review Letters. 2013, 110, 215501-5.

6. K Askin, C Shen, ZV Guo and S Ramanathan. Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behavior. Nature. 2012, 490, 273–277.

7. ZV Guo, AC Hart and S Ramanathan. Optical interrogation of neural circuits in Caenorhabditis elegans. Nature Methods. 2009, 6, 891-896.

8. ZV Guo and L Mahadevan. Limbless undulatory propulsion on land. Proceedings of the National Academy of Sciences. 2008, 105(9), 3179-3184.