祁海

 

电子邮件: qihai(at)mail(dot)tsinghua(dot)edu(dot)cn 

电话:+86-10-62796757

 

科研方向:

   多细胞互作和细胞间信息传递是免疫系统正常工作的必要基础。生发中心反应是体液免疫记忆的重要源头，其正常组织结构和细胞互作都受到精细的动态调控。深入理解这些调控机制，是更加合理地设计预防或治疗性抗体疫苗的前提。我们通过遗传、生化、细胞生物学手段以及活细胞、活组织动态成像方法试图理解以下问题：（1）在生发中心反应中关键性细胞互作的分子调控机理；（2）这些细胞互作的定性及定量特点如何参与细胞命运选择；（3）生发中心及滤泡组织结构的时空动态演化特点及分子调控机制；（4）以上3个层次的组织与调节机制如何保持免疫系统在产生有效应答的同时避免自身反应。

 

   上述这些成熟的研究方向以外，我们还开展研究病毒感染时CD8组织驻留记忆的形成、小胶质细胞形态与功能、以及可能参与调控免疫应答的神经环路。通过这些研究，我们试图理解免疫细胞间、免疫细胞与微环境间、免疫系统与其它系统间的交互作用，如何共同维持器官的功能稳态。

 

Selected publications:

1. Heping Xu, Xuanying Li, Dan Liu, Jianfu Li, Xu Zhang, Xin Chen, Shiyue Hou, Lixia Peng, Chenguang Xu, Wanli Liu, Lianfeng Zhang, and Hai Qi^#. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496:523-527, 2013.

2. Dan Liu^*, Heping Xu^*, Changming Shih, Zurong Wan, Xiaopeng Ma, Weiwei Ma, Dan Luo, and Hai Qi^#. T-B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517:214-218, 2015.

3. Xin Chen^*, Shan Tang^*, Ji-Shen Zheng^*, Ruozhu Zhao, Zhi-Peng Wang, Wen Shao, Hao-Nan Chang, Jing-Yuan Cheng, Hui Zhao, Lei Liu^#, and Hai Qi^#. Chemical synthesis of a two-photon-activatable chemokine and photon-guided lymphocyte migration in vivo. Nature Communications 6:7220, 2015.

4. Ran He^*, Shiyue Hou^*, Cheng Liu^*, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Jianqing Xu, Hai Qi^#, Yuzhang Wu^# and Lilin Ye^#. Follicular CXCR5-expressing CD8 T cells curtail chronic viral infection. Nature, 537:412-428, 2016.

5. Peiwen Lu^*, Changming Shih^*, and Hai Qi^# Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function. Science 356:eaai9264, 2017.

6. Jiacong Yan, Bo Liu, Yan Shi, Hai Qi^#. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. Journal of Experimental Medicine, 214:319, 2017.

7. Hu Yan^*, Longyan Wu^*, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, and Hai Qi^#. Plexin B2 and Semaphorin 4C guide T-cell recruitment and function in the germinal center. Cell Reports, 19:995-1007, 2017.

8. Yifeng Wang^*, Jingwen Shi^*, Jiacong Yan^*, Zhengtao Xiao, Xiaoxiao Hou, Peiwen Lu, Shiyue Hou, Tianyang Mao, Wanli Liu, Yuanwu Ma, Lianfeng Zhang, Xuerui Yang and Hai Qi^#. Nature Immunology, 18:921-930, 2017.

9. Jingwen Shi, Shiyue Hou, Qian Fang, Xin Liu, Xiaolong Liu, and Hai Qi^#. Regulation of follicular T-helper cell positioning and function by PD-1. Immunity, 49:264-274, 2018.

10. Ruozhu Zhao, Xin Chen, Weiwei Ma, Jinyu Zhang, Jie Guo, Xiu Zhong, Jiacheng Yao, Jiahui Sun, Julian Rubinfien, Xuyu Zhou, Jianbin Wang and Hai Qi^#. A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity. Nature, 577:416-420, 2020.

11. Xu Zhang^*, Bo Lei^*, Yuan Yuan^*, Li Zhang^*, Lu Hu, Sen Jin, Bilin Kang, Xuebin Liao, Wenzhi Sun, Fuqiang Xu, Yi Zhong^#, Ji Hu^# and Hai Qi^#. Brain control of humoral immune responses amenable to behavioral modulation. Nature, 581:204-208, 2020.