尹玉新
电子邮件: yinyuxin@hsc.pku.edu.cn
电话: +86-10-8280-5570 (office)
实验室主页: http://www.isb.pku.edu.cn
办公室地址：北京市海淀区学院路38号北京大学医学科技楼B1001
研究方向：
尹玉新团队多年来一直从事肿瘤发生机理的研究，主要关注抑癌基因PTEN及其家族在DNA复制与基因组稳定性、肿瘤代谢与肿瘤免疫中的作用。尹玉新教授对p53 和PTEN 两个重要抗癌基因进行了系统性和创造性研究，为揭示肿瘤发生发展的机理做出了重大贡献。在肿瘤免疫方面，发现了免疫防御的调控机理，为肿瘤免疫确定了新方向。尹玉新团队还致力于肿瘤的早期诊断，最近开发出人工智能辅助的早期肿瘤代谢检测方法，可用于癌症的大规模早期筛查。
研究课题：
1. 多组学分析肿瘤异质性
2. 肿瘤微环境与转移机理
3. 肿瘤免疫与细胞治疗
4. 生物大分子结构解析与新药研发
在研国家级项目：
1) PTEN家族蛋白及circPTEN对肿瘤发生发展的调控机制研究（国家自然科学基金重点项目）
2) 肿瘤细胞恶性转化、侵袭转移的可塑性调控网络及分子机制（国家重点研发计划生物大分子与微生物组专项课题）
获奖情况：
研究团队2017年获“中华医学科技奖”二等奖
代表性科研论文：
1. Yin, Y., Tainsky, M. A. Bischoff, F. A., Strong, L.C. and Wahl, G. M. (1992). Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
2. Yin, Y., Terauchi, Y., Solomon, G. G., Aizawa, S., Rangarajan, P. N., Yazaki, Y., Kadowaki, T, and Barrett, J. C. (1998). Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391: 707-710.
3. Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C. (2003). PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422:527-531.
4. Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.* (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128: 157-170.
5. Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M.A., Shen, W.H.,* and Yin, Y.*. (2014). PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function. Cell Metab. 19, 836-848.
6. Wang, G., Li, Y., Wang, P., Liang, H., Cui, M., Zhu, M., Guo, L., Su, Q., Sun, Y., McNutt, M.A., and Yin, Y.*. (2015). PTEN regulates RPA1 and protects DNA replication forks. Cell Res. 25, 1189-1204.
7. Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M.A., and Yin, Y.*(2015).The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol., 16, 1263-1273.
8. Lu, D., Liu L, Sun Y, Song J, Yin Q, Zhang G, Qi F, Hu Z, Yang Z, Zhou Z, Hu Y, Zhang L, Ji J, Zhao X, Jin Y, McNutt MA, Yin, Y.*(2020). The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity. Nat Immunol., 21, 287-297.
9. Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*. (2022). Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis. Sci Transl Med., 14(630):eabk2756.
10. Zheng L, Liang H, Zhang Q, Shen Z, Sun Y, Zhao X, Gong J, Hou Z, Jiang K, Wang Q, Jin Y, Yin, Y*. (2022). circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling. Mol Cancer. 21(1):41.
*Corresponding author